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Frequency and prognost...

Frequency and prognostic factors of olfactory dysfunction after traumatic brain injury Main Image

Frequency and prognostic factors of olfactory dysfunction after traumatic brain injury

Fri 20 Jul 2018

To assess the frequency and factors associated with posttraumatic olfactory dysfunction, including anosmia, in a follow-up of patients with moderate and severe traumatic brain injury (TBI).

Methods: The setting was a cross-sectional study of patients that were consecutively included in the Trondheim TBI database, comprising injury-related variables. Eligible participants 18–65 years were contacted 9–104 months post trauma and asked olfactory-related questions. Those reporting possible posttraumatic change of olfaction were invited to further examination using the Sniffin’ Sticks panel.

Results: Of 211 eligible participants, 182 (86.3%) took part in telephone interviews and 25(13.7%) were diagnosed with olfactory dysfunction. 60% of these, or 8.2% of all participants, had anosmia. In age-adjusted logistic regression analyses, fall (OR 2.5, 95% CI 1.0–6.2), skull base fracture (OR 2.9, 95% CI 1.2–7.1) and cortical contusion(s) (OR 6.0, 95% CI 2.1–17.3) were associated with olfactory dysfunction. In an analysis of anosmia, fall (OR 3.4, 95% CI 1.1–10.6) and cortical contusion(s) (OR 19.7, 95% CI 2.5-156.0) were associated with the outcome.

Conclusion: Of the study participants 13.7% had olfactory dysfunction and 8.2% had anosmia. Higher age, trauma caused by fall and CT displaying skull base fracture and cortical contusion(s) were related to olfactory dysfunction.


Reference: Bratt, M., Skandsen, T., Hummel, T., Moen, K.G., Vik, A., Nordgård, S., & Helvik, A.S. (2018). Frequency and prognostic factors of olfactory dysfunction after traumatic brain injury. Brain Injury, 32 (8), 1021 - 1027.  


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